Cyclic Sulfamidite as Simultaneous Protecting Group for Amino Alcohols: Development of a Mild Deprotection Protocol Using Thiophenol
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چکیده
منابع مشابه
Efficient and chemoselective alkylation of amines/amino acids using alcohols as alkylating reagents under mild conditions.
We report a mild and environmentally benign method for the synthesis of tertiary amines using alcohols as the alkylating reagents. Not only secondary amines such as piperazines but also amino acids and amino alcohols can be N-alkylated selectively. For N,O-benzyl protected amino alcohols, both N,O-de-benzylation and N-methylation were achieved in one-pot.
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Amines, amides and ethers containing 2-arylallyl groups are selectively and easily deprotected with tert-butyllithium. This transformation probably involves a carbolithiation reaction of the styrenyl moiety followed by a beta-elimination process.
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2020
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.c20-00531